Background: Computed Tomography guided Fine needle aspiration cytology of lung mass is an effective modality to diagnose lung cancer. Its use has been extended in differentiating lung tumors into various cytomorphological types so that it becomes easier for further treatment. The study is aimed to study the morphological features of various types of lung lesions, correlate with histopathology wherever possible and evaluate the sensitivity, specificity, and accuracy of fine needle aspiration cytology procedure. Materials and Methods: It is an observational cross-sectional study conducted in the Department of Pathology of Gandaki Medical College and Teaching Hospital from April 2018 to December 2020 and 109 cases were included. Results: In the study, 109 cases were included, female were 61(56%) while males were 48(44%) with an M: F ratio is 1:1.2. The maximum number of cases was seen in the age >70 years (45.9%), mean age being 68.4years. Smoking was seen in 66(60.6%) cases. Squamous cell carcinoma (SCC) 32( 29.4%) was the most common cytological finding followed by adenocarcinoma 20(18.3%). Similarly, SCC was the most common histopathological finding which comprised 30( 53.5%) followed by adenocarcinoma 14(25%). Fine needle aspiration cytology and histopathological diagnosis are significantly associated with a p-value <0.001. The sensitivity, specificity, and accuracy of fine needle aspiration cytology were 76%,80%, and 76.6% respectively. Conclusions: Computes tomography-guided fine needle aspiration cytology is a relatively safe, inexpensive, and accurate procedure in the diagnosis of different lung lesions for early diagnosis and appropriate treatment.

Introduction: Fine needle aspiration cytology (FNAC) is the important part of triple assessment in diagnosing the palpable breast lump. It categorizes the lesion into benign, malignant and its subtypes. It can also identify the residual diseases after treatment.

Introduction: Swelling of the thyroid gland is a commonly encountered clinical problem in all age groups whether benign or malignant. Fine Needle Aspiration Cytology (FNAC) of the thyroid lesions along with hormonal function test helps in the proper preoperative assessment. Ultimately it changes clinical management and improves the patient outcome.Objectives: To describe the cytomorphological features of palpable thyroid nodules using fine needle aspiration cytology (FNAC) along with the assessment of thyroid hormonal status of the patient.Methods: The study was conducted in the Department of Pathology of Gandaki Medical College and Teaching hospital from January 2017 to December 2017 and included 50 patients with thyroid lesions. Cytological assessment was done using FNAC along with serological assessment of thyroid hormones.Results: In the study 50 cases of thyroid swelling were included and evaluated by cytological and hormonal analysis which comprises of 10% males and 90% females with a with a female to male ratio of 9 : 1. Maximum number of cases was seen in the age range 41 - 60 years (46%), mean age being 44.6 years. The cytological diagnosis comprised colloid goiter (58%), lymphocytic thyroiditis (16%), Hashimoto thyroiditis (10%). Thyroid hormone analysis showed 66% euthyroid, 22% hypothyroid and 12% hyperthyroid.Conclusions: The study showed that FNAC and TFT profile both are essential for the proper management of thyroid lesions. FNAC along with hormonal analysis helps in proper patient assessment and management. J-GMC-N | Volume 11 | Issue 01 | January-June 2018, Page: 17-22

Introduction: Leprosy is chronic granulomatous disease caused by Mycobacterium leprae. Clinically diagnosed cases of leprosy can be evaluated by punch biopsy. It can be classified according to Ridley and Jopling Classification. Objective: To study the different spectrum of leprosy and its Bacillary Index (BI), evaluate the agreement between clinical and histopathological diagnosis. Materials and Methods: This is a hospital based cross sectional retrospective study done for the period of 6 months from January to June 2019. The data were subjected to kappa analysis by using SPSS version 24 to see the agreement between clinical and histopathological diagnosis. Results: Out of 62 cases of clinically diagnosed cases of leprosy three (4.83%) cases turned out to be other granulomatous diseases. According to Ridley and Jopling classification, clinical and histopathological agreement was seen in 38 (61.29%) cases. Agreement of 100% was seen in Indeterminate leprosy (IL) and Borderline tuberculoid leprosy (BT). The BI was more in Lepromatous leprosy (LL), Borderline lepromatous (BL) whereas IL, BT and Tuberculoid leprosy (TT) showed less BI. Overall there was moderate agreement between clinical and histopathological diagnosis (kappa- 0.505) which was statistically significant (p value <0.05). Conclusion: There was moderate agreement between the clinical and histopathological diagnosis of subtype of leprosy. The Bacillary load was high in LL whereas least in TT and is determined by immune system.

Hypertrophic gastropathy is a rare idiopathic hyperproliferative disorder which may present as Menetrier’s disease (MD) characterized by foveolar hyperplasia in the gastric fundus and body. It is often accompanied by a severe loss of plasma proteins (including albumin) from the altered gastric mucosa. The disease occurs in two forms, a childhood form due to cytomegalovirus infection and an adult form attributed to overexpression of transforming growth factor-alpha (TGF-α). The most common symptoms include epigastric pain with fullness and vomiting and generalized peripheral edema with hypoalbuminemia. We present a case of 75-year-old female presenting with epigastric pain and vomiting. Upper gastrointestinal endoscopy and computed tomography scan revealed an irregular mucosal fold at the body and antrum and thickening of the stomach wall, respectively. Though the endoscopic gastric mucosal biopsy was nonspecific, the patient underwent partial gastrectomy due to clinicoradiological suspicion of carcinoma. On histopathology, the case was reported as hypertrophic gastropathy, consistent with MD. Though there is a strong clinical and radiological suspicion of malignancy in the hypertrophied gastric mucosa, MD should be one of the important differential diagnoses.