Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.

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The rise of right-wing populists in Western Europe has often been linked to their ability to exploit social media affordances to fuel anger. While scholarship has already examined the emotional dimension of the populist right’s online communication, with some researchers studying specifically the fuelling of anger among social media users, we still lack empirical proof of the mobilizational effectiveness of what we describe as “anger-triggering communication.” To explore this question, in this article, we develop a statistical and topic analysis of right-wing populists’ Facebook pages in Italy, France, Spain, and Germany during the 2019 European Union (EU) election campaign. We find that (a) right-wing populists on Facebook have a significantly higher number of “Angry” Facebook reactions per post compared to their political adversaries; (b) there is a positive and significant effect of the number of Angry reactions on the number of times a post is shared; (c) Angry reactions and Shares are overrepresented in posts on immigration and security, but anger-fuelled mobilization is not limited to these topics. These findings contribute to the scholarship on social media, emotional communication, and populism, adding insights on the mobilizational effectiveness of negative campaigning. The article highlights that stoking public anger, especially around controversial issues such as immigration and security, is a rewarding tactic because it increases motivational strength, and contributes to triggering high-threshold interactions such as sharing, which, in turn, are key for achieving virality in the diffusion of political messages.

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