The crystal structure of the novel methylene-bridged tetraorganodistannoxane ([Ph(HO)SnCH2Sn(I)Ph]O)4 (1) depends on the solvent it is crystallised from and is controlled by hydrogen bridges and interhalogen interactions.

Reaction of the dimethylsilylmethyl-substituted tetraorganotin derivative CH 2 [CH 2 Sn-(Ph 2 )CH 2 Si(H)Me 2 ] 2 (1) and CH 2 [CH 2 Sn(Ph 2 )CH 2 Si(i-PrO)Me 2 ] 2 (3), respectively, with mercuric chloride afforded the novel silicon-and tin-containing 10-and 20-membered rings cyclo-CH 2 [CH 2 Sn(Cl 2 )CH 2 Si(Me 2 )] 2 O (4) and cyclo-CH 2 [CH 2 Sn(Cl 2 )CH 2 Si(Me 2 )OSi(Me 2 )CH 2 -Sn(Cl 2 )CH 2 ] 2 CH 2 (5). Both compounds 4 and 5 can be converted into the soluble Lewis acidic polymer poly-[Si(Me 2 )CH 2 Sn(Cl 2 )(CH 2 ) 3 Sn(Cl 2 )CH 2 Si(Me 2 )O] (8). 119 Sn NMR studies indicate that 4 acts as a bidentate Lewis acid toward chloride ions, exclusively forming the 1:1 complex [cyclo-CH 2 [CH 2 Sn(Cl 2 )CH 2 Si(Me 2 )] 2 O‚Cl] -[(Ph 3 P) 2 N] + (7). The molecular structures as determined by single-crystal X-ray diffraction analysis of 4 and 7 are reported.

In line with priorities set by the Italian Ministry of Health and international literature, the “Crisalide project” provides specific care pathways aimed at young adults (YA) with severe mental disorders (SMD). As described in Materials and Methods, it consists of three lines of activity: transition to adult mental health services (TSMREE/CSM 17–19); Diagnostic, Therapeutic, and Assistance Pathways for Young Adults (PDTA-YA); high-intensity treatment center for young adults “Argolab2 Potential Space”. The aim of the study is to assess the results relating to the first three years of implementation of this clinical-organizational model (2018/2020) according to the process indicators identified by the ministry. Among the population aged 18–30 under treatment, results show increased prevalence (30%) and incidence (26%); 0% treatment conclusions due to the expiration of the conventional time limit; 0% involuntary hospitalizations (TSO); 0% STPIT hospitalizations; 0% repeated hospitalizations; 0% hospitalizations in the common mental disorders diagnostic group. Among the population of Argolab2 Potential Space, 45.4% have resumed studies; 40.9% have had a first work experience; 22.7% have obtained educational or training qualifications, and 18.2% live in independent houses. At a time when the academic literature underlines the terrible impact of the COVID-19 pandemic on this population, the present study confirms that specific treatment processes for young populations are a protective factor.

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