Glioblastoma multiforme (GBM), comprised of astrocytes, is the most common brain tumor of the central nervous system. Although extracranial metastasis of GBM is very rare (<2%), when it occurs, the lungs are the most common site. Presently described are the cases of 2 male patients, aged 55 and 69 years, who were ultimately diagnosed with pulmonary metastasis of GBM. A lesion that appears to be a primary malignancy on lung imaging may, in fact, be a metastasis. Treatment of the primary malignancy can lead to regression. A detailed anamnesis, evaluation of accompanying diseases, and a pathological diagnosis are of vital importance.

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