A synthetic approach
toward densely substituted enantiopure cyclic
sulfinamides possessing up to four consecutive stereogenic centers
was developed based on a completely diastereoselective S
N
2′ cyclization/
tert
-Bu cleavage sequence.
Diastereospecific transformation of the obtained scaffold into chiral
S
VI
derivatives such as sulfoximines and sulfonimidamides
is demonstrated.
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