We recruited patients who were admitted to UMMC, Kuala Lumpur, Malaysia, for AIS between February 2012 and August 2016. The data of consecutive patients from the stroke thrombolysis registry was recorded. The inclusion and exclusion criteria for stroke thrombolysis were based on the National Institute of Neurological Disorders and Stroke trial in the United States. (10) The baseline demographic and clinical data of patients, including age, gender, ethnicity, vascular risk factors, stroke subtypes, blood pressure on admission, National Institutes of Health Stroke Scale (NIHSS)