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The preliminary results of this investigation indicate that physicochemical and HS-GC-MS analysis, together with multisensory system coupled with chemometric techniques, presented a satisfactory performance regarding olive oil sample discrimination and identification. © 2017 Society of Chemical Industry.

Red blood cells (RBC) have emerged as a novel regulatory cell type endowed with bioactivities toward activated human T cells. Herein we show that the RBC bioactivities act on intracellular pathways initiated by T cell receptor (TCR)-dependent and -independent stimuli,including IL-2, IL-15, and the mixture of phorbol dibutyrate and ionomycin. The RBC bioactivities preserve the antioxidant status and are capable of rescuing activated T cells from cell death induced by serum deprivation. They are not mediated by glycosylphosphatidylinositol-linked receptors or sialic acids, and kinetic studies revealed that they hasten the entrance into the cell cycle. By using cyclosporine A (CsA) and rapamycin (Rapa) we show that the RBC bioactivities are calcineurin-dependent. Thus, treatment of T cells with CsA, but not Rapa, impaired RBC bioactivities, and preincubation of RBC with CsA completely abolished their bioactivities. We have demonstrated that RBC carry out bioactivities that are sensitive to CsA.

Cyber-Physical Systems (CPS) are a prominent component of the modern digital transformation, which combines the dynamics of the physical processes with those of software and networks. Critical infrastructures have built-in CPS, and assessing its risk is crucial to avoid significant losses, both economic and social. As CPS are increasingly attached to the world’s main industries, these systems’ criticality depends not only on software efficiency and availability but also on cyber-security awareness. Given this, and because Failure Mode and Effect Analysis (FMEA) is one of the most effective methods to assess critical infrastructures’ risk, in this paper, we show how this method performs in the analysis of CPS threats, also exposing the main drawbacks concerning CPS risk assessment. We first propose a risk prevention analysis to the Communications-Based Train Control (CBTC) system, which involves exploiting cyber vulnerabilities, and we introduce a novel approach to the failure modes’ Risk Priority Number (RPN) estimation. We also propose how to adapt the FMEA method to the requirement of CPS risk evaluation. We applied the proposed procedure to the CBTC system use case since it is a CPS with a substantial cyber component and network data transfer.

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