The copper-mediated aerobic oxidative cleavage of a,b-unsaturated ketones to synthesize 1,2-diketones by using potassium acetate as a catalyst and sodium iodide as a promoter in acetic acid is described. The protocol has the advantages of using inexpensive and non-toxic raw materials, high yield and simple work-up procedure.Scheme 1 The general synthetic methods for 1,2-diketones.Scheme 2 Synthesis of 1,2-diketones by oxidative cleavage.Scheme 3 Synthesis of 1,2-diketones from chalcones.

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An efficient method for copper catalyzed synthesis of 1,3,5-triarylpentane-1,5-diones using a,bunsaturated ketones as unique starting materials is described. The protocol offers several advantages such as simple, inexpensive reagents, mild reaction conditions and simple work-up procedure.

Using an efficient aerobic oxidative method, the synthesis of ten 3,5-disubstituted isoxazoles by treatment of α,β-unsaturated ketones with hydroxylamine and NaOH at room temperature has been achieved.

Copper-Catalyzed Synthesis of 1,3,5-Triarylpentane-1,5-diones from ,-Unsaturated Ketones. -(LI*, Z.; WEN, G.; HE, L.; LI, J.; JIA, X.; YANG, J.; RSC Adv. 5 (2015) 64, 52121-52125, http://dx.