A review of the most recent and updated literature on the current global situation of Neisseria Gonorrhoeae infections is presented. According to the Center for Disease Control and Prevention (CDC), Neisseria Gonorrhoeae infection is one of the most important threats of antibiotic resistance in the United States and the world. In 1970 the first reports of resistance by isolating penicillinase-producing strains were identified and more recently, ceftriaxone-resistant N. gonorrhoeae strains have appeared. In Mexico, so far, there are no reports of ceftriaxone-resistant Neisseria gonorrhoeae; however, the first report dates from 1987 where De la Cruz and collaborators reported that up to 26.3% of gonorrhea isolates from 148 patients were penicillinase-producing strains. The emergence of N. Gonorrhoeae strains resistant to relatively modern and very useful antibiotics in daily medical practice raises awareness of the clinical and microbiological landscape in which we find ourselves, that is why alternative therapies such as vaccines and new drugs with antibiotic potential that address emerging resistance need to be considered.