No abstract

The aim of this study was to evaluate the possibility of using the anti-varicella zoster virus (anti-VZV, also known as anti-HSV3) vaccine against orobuccal herpes simplex virus type 1 (HSV1) and genital herpes simplex virus type 2 (HSV2). This was suggested by study of the phylogenetic tree of members of the herpes virus family, which showed a close relationship between VZV (HSV3) and the HSV1 and HSV2 herpes viruses. Methods: The present prospective study was conducted from January 2005 through January 2011. Twenty-four patients afflicted with HSV1 and HSV2 herpes recurrences over a period of years, numbering 6-8 and more recurrences per year, agreed to receive the anti-VZV vaccine. They were compared with 26 nonvaccinated patients presenting with herpes simplex diseases 2-5 times a year. All 50 patients were documented with anti-HSV1, anti-HSV2, and anti-VZV antibody serological testing. Results: From 2005 through 2011, for the 24 anti-VZV vaccinated patients, the average number of herpes relapses decreased to 0, correlated with an increased anti-VZV antibody level and clinical recovery of all patients, whereas no improvement was observed for the 26 nonvaccinated herpes patients. Conclusion: Data for the anti-VZV serological antibody levels tested before and after anti-VZV vaccination showed a significant (P , 0.001) increase among vaccinated patients. This suggests defective anti-VZV immune power in these patients. After 6 years of positive results for anti-VZV vaccine, this is a logical and fair hypothesis. We can now undertake a randomized study to confirm these findings.

No abstract

La gestión de riesgos requiere análisis, contextualización y propuestas para responder a factores internos y externos que impactan la consecución de los objetivos y limitan el aprovechamiento de las oportunidades. Esta investigación tiene como propósito ofrecer a empresarios una recopilación de herramientas prácticas que podrán ser ejecutadas para implementar, gestionar y hacer seguimiento al análisis de los riesgos empresariales. Se realizó una revisión bibliográfica con base en el marco de referencia planteado por COSO ERM (2017), IIA (2013) y la ISO 31000:2018. Se realizó un estudio de caso en una empresa colombiana, dedicada a la producción y distribución de alimentos, donde se aplicó a los miembros de la alta dirección un instrumento que permitió conocer la severidad del riesgo, así como el valor Phi consultado a los miembros de la Junta Directiva. Se concluye que la gestión de riesgos pasa a ser una actividad de aplicación

No abstract