Dyspepsia is a common complaint among individuals seeking medical care as well as in general population. Non-Ulcer Dyspepsia (NUD) also known as Functional Dyspepsia (FD) occupies a larger space. Prevalence of NUD is about 20-30% worldwide. In India, about 7.6% to 49% of Indian population report NUD symptoms annually. Ayurveda vividly describes Gastro-Intestinal (GI) diseases in the context of Amlapitta (NUD). The aim of this study is to evaluate the effectiveness of Nisthusha (dehusked) Yavaadi Kashaya (Medicated decoction) in the management of Amlapitta (NUD). A 21 -years old male patient, visited the Kayachikitsa OPD, Pankajakasthuri Ayurveda Hospital, Kattakkada, Thiruvananthapuam on 28-05-2018, with the complaints of Post-Prandial Fullness, Early satiety and Epi-gastric pain with general weakness of the body for 4 months. Irregular dietary habits, untimely food intake, outside food-stuffs of him lead to this condition. The patient was advised to take 48ml of Nisthusha(dehusked) yavaadi Kashaya (Medicated decoction) in BD dose before food, with Trijataka (Twak, Ela, Patra) Choorna (Powder) 1g as prakshepaka dravya (adjuvant sprinkled over the medicated decoction which is to be consumed) followed by Mudga (Green Gram) Yusha (Soup preparation) 48ml dose as BD as Anupana (Adjuvant) for 15 days. Assessments were done on the 0 th , 15 th , & 30 th day where, marked changes were noted subjectively through the grading scale. This effective treatment proved to be a non-invasive safe therapy in the management of Amlapitta (NUD).