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IntroductionPatients rarely accept colonoscopy without anxiety because the procedure is commonly associated with significant pain (1). Different agents were investigated to increase patient comfort and technical performance of colonoscopy with variable success and adverse events profiles (2). Diclofenac inhibited visceral pain signals on colonic stretching in animal studies (3).MethodWe have conducted a single-centre randomised study to evaluate the analgesic effect of diclofenac versus placebo in patients undergoing unsedated colonoscopy. Patients were randomised to receive 100 mg of diclofenac (Group 1) or placebo (Group 2). We used a 10-point VAS scale for pain. Mann-Whitney test was used to compare mean pain index and time to discharge. Spearman’s test was used for correlation between caecal intubation rates and pain.ResultsWe recruited a total of 88 patients divided into 2 groups: 43 (48.9%) in intervention group and 45 (51.1%) into placebo group. Baseline characteristics of patients did not differ significantly. There was no difference between groups in pain during colonoscopy (Mann-Whitney; Z=−0.84; p=0.40) or in grading of colonoscopy experience (1–10 scale) (Mann-Whitney; Z=−0.99; p=0.32), or number of patients that would repeat colonoscopy. There wasn’t any significant correlation between caecal intubation time and pain scale values (Spearman’s r=0.17; p=0.20). A significant correlation between caecal intubation time and pain scale values was found in placebo group (Spearman’s r=0.37; p=0.04) but not in intervention group (Spearman’s r=−0.08; p=0.71). Two lethal outcomes were recorded, both in the placebo group (4.4%; p=0.50%). Time to discharge in days was also not significantly different (Mann Whitney; Z=−0.18; p=0.85).Abstract PTH-030 Figure 1ConclusionThere does not seem to be an effect of diclofenac on pain during unsedated colonoscopy compared with placebo.References. Denberg TD, Malhado TV, Coombes JM. Predictor of nonadherence to screening colonoscopy. J Gen Intern Med2005:11;989.. Triantafillidis JK, Merikas E, Nikolakis D, Papalois AE. Sedation in gastrointestinal endoscopy: current issues. World J Gastroenterol 2013;19:463–81.. Gold MS, Zhang L, Wrigley DL, Traub RJ. Prostaglandin E2 modulates TTXR I(Na) in rat colonic sensory neurons. J Neurophysiol 2002;88:1512–22.Disclosure of InterestNone Declared

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