Nanomedicine are a relatively new but quickly expanding discipline in which tiny materials are used as diagnostic instruments or to administer therapeutic drugs to particular targets in a controlled manner. Nanotechnology provides a number of advantages in the treatment of chronic human diseases by allowing precise medications to be delivered to particular locations. There have been several notable uses of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, etc.) in the treatment of various illnesses in recent years. Neverthless, In current scenario there are phytochemicals are also present whom are responsible for prevention of devastating diseases. In this review it has been highlighted that there are real possible outcomes present, in the case of the combined treatment strategies of phytochemicals and nanoparticles. Eventually, this combined drug delivery system play crucial role in anti-cancer, anti-alzehimar, anti-bacterial and many more complicated maladies. We also focused on the preclinical and clinical study regarding the drug delivery system. Here, the types of phytochemicals along with their bioavilability also mentioned. Additionally, the Nanomedicines' advantages and disadvantages in drug delivery from synthetic to natural sources to clinical applications are also explored. In addition, we've added information about nanomedicine's developments by attaching with phytochemicals with respect to the diseases and future prospects.