Background: Plasmodium apicoplast protein synthesis is essential, but few apicoplast tRNA synthetases have been characterized. Results: Apicoplast glutamyl-tRNA synthetase aminoacylates tRNA Glu and tRNA Gln , is sensitive to a bacterial inhibitor, and is essential in blood stages.
Conclusion: Formation of apicoplast Gln-tRNAGln is via indirect aminoacylation. Significance: We demonstrate that the apicoplast glutamyl-tRNA synthetase is a potential drug target.
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