Background:The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients with healthy periodontium and investigate the effects of periodontal treatment on the levels of these molecules.Methods: GCF samples were collected from periodontally healthy controls (C group, n = 20), patients with gingivitis (G group, n = 20), and patients with chronic periodontitis (CP group, n = 20). Sampling sites were also divided into bleeding (BP) and non-bleeding (NBP) periodontal pocket groups in CP group. Full-mouth clinical periodontal parameters were also recorded. GCF samplings and clinical records were also repeated at 1 and 3 months after treatment for the CP group. SEMA4D, PAD2, and MMP-8 levels were determined by enzyme-linked immunosorbent assay. Results:The GCF SEMA4D, PAD2, and MMP-8 total amounts were similar in CP and G groups (P ˃ 0.05) but significantly greater than the C group (P ˂ 0.05). The GCF SEMA4D and PAD2 total amounts in the BP group were significantly greater than the NBP group (P ˂ 0.05). GCF MMP-8 total amounts were similar in BP and NBP groups (P ˃ 0.05). The GCF SEMA4D, PAD2, and MMP-8 total amounts were significantly reduced at first month after treatment (P ˂ 0.05). There were positive correlations between GCF total amount of SEMA4D and all clinical parameters (P ˂ 0.01) and also between PAD2 and clinical parameters (P ˂ 0.05) except clinical attachment level.There was a positive correlation between GCF total amount of SEMA4D and GCF total amount of MMP-8 (P ˂ 0.05). Conclusions:It may be suggested that SEMA4D and PAD2 are related to periodontal disease. Their GCF total amounts may have a diagnostic potential. Additional studies would better clarify their role in periodontal diseases. K E Y W O R D Sgingival crevicular fluid, peptidylarginine deiminase, periodontal diseases, semaphorins J Periodontol. 2019;90:973-981.
ÖZET Amaç: Maksiller sinüs, bulunduğu bölge itibarıyla hem kulak burun boğaz hem de ağız diş ve çene cerrahisi doktorlarının sıklıkla karşılaştığı bölgelerden birisidir. Literatürde de odontojenik enfeksiyonlar ile maksiller sinüzit arasındaki ilişki sıklıkla gösterilmiştir. Sinüs tabanı yükseltme operasyonu sırasında lateral pencerenin doğru tasarımını yapmak için septanın radyografik olarak tanımlanması önemlidir. Bu çalışmanın amacı, maksiller sinüs septası gibi maksiller sinüs morfolojilerinin ve patolojilerinin varlığını ve konumunu belirlemede konik ışınlı bilgisayarlı tomografi (KIBT) ve panoramik radyografi yöntemlerinin karşılaştırılmasıdır. Gereç ve Yöntemler: Bu çalışma, Eylül 2010 ve Eylül 2021 tarihleri arasında ağız, diş ve çene cerrahisi bölümüne başvurmuş hastaların KIBT ve panoramik röntgen görüntülerinin retrospektif olarak incelenmesi ile gerçekleştirilmiştir. Bulgular: KIBT görüntülerinde, toplam 214 hastanın 64'ünde (%30) ve 410 sinüsün 112'sinde (%27,3) maksiller sinüs septası tespit edildi. Panoramik radyografi görüntülerinde ise toplam 214 hastanın 44'ünde (%20,5) ve 410 sinüsün 89'unda (%21,7) maksiller sinüs septası tespit edildi. KIBT görüntülerinde, maksiller anterior bölgede 30 (%7,3), orta bölgede 70 (%17,1), posterior bölgede 6 (%1,5) ve aynı anda bu 3 bölgelerden herhangi 2'sinde yer alan 6 (%1,5) septa tespit edildi. Panoramik radyografide maksiller anterior bölgede 14 (%3,4), orta bölgede 61 (%68,5), posterior bölgede 8 (%9) ve aynı anda bu 3 bölgelerden herhangi 2'sinde yer alan 3 (%3,3) septa tespit edildi. Sonuç: Sinüs tabanı yükseltme operasyonu sırasında komplikasyonlardan kaçınmak için panoramik radyografinin bu yapıların tanımlanmasında düşük bir duyarlılığa ve özgüllüğe sahip olduğu kanıtlanmış olduğu için tercihen bilgisayarlı tomografi ile çalışılması gereklidir. Anah tarKe li me ler: Maksiller sinüs; patoloji; konik ışınlı bilgisayarlı tomografi; panoramik radyografi; anatomik varyasyon ABS TRACT Objective: Due to region of maxillary sinus it is one of the region both department of ear, nose and throat and department of oral and maxillofacial surgery are frequently encountered relationship between odontogenic infections and maxillary sinusitis has been shown in literature. For correct design of the lateral window during sinus floor elevation operation, radiographic identification of septa is important. The aim of this study is to compare cone-beam computed tomography (CBCT) and panoramic radiography methods in determining the presence and location of maxillary sinus septa and pathologies. Material and Methods: This study was performed with CBCT and panoramic images of patients in department of oral and maxillofacial surgery between September 2010 and September 2021, retrospectively. Results: In CBCT images, 64 (30%) of 214 patients and 112 (27.3%) of 410 sinuses had maxillary sinus septa. In panoramic images, 44 (20.5%) of 214 patients and 89 (21.7%) of 410 sinuses had maxillary sinus septa. In CBCT images, 30 (7.3%) in the anterior region, 70 (17.1%) in the middle reg...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.