Municipal waste management has become a challenging issue with the rise in urban populations and changes in people’s habits, particularly in developing countries. Moreover, government policy plays an important role associated with municipal waste management. Thus, this research proposes the regional location routing problem (RLRP) model and multi-depot regional location routing problem (MRLRP) model, which are extensions of the location routing problem (LRP), to provide a better municipal waste collection process. The model is constructed to cover the minimum number of depot facilities’ policy requirements for each region due to government policy, i.e., the large-scale social restrictions in each region. The goal is to determine the depot locations in each region and the vehicles’ routes for collecting waste to fulfill inter-regional independent needs at a minimum total cost. This research conducts numerical examples with actual data to illustrate the model and implements a hybrid genetic algorithm and simulated annealing optimization to solve the problem. The results show that the proposed method efficiently solves the RLRP and MRLRP.

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