Distinct technological trends seriously influence the modern software architectures. In this paper, four different software architectures and framework combinations were generally compared. The basis for the analysis is the developer's productivity. In a 3 year-long research and development project, a real-world telemedicine application was efficiently implemented four times with various software architectures and architectural patterns. More than 5,000 person-hours were spent on carrying out them. At present, a unique dataset is available, which provides the opportunity to compare the cost of spent person-hours in different approaches. The goal of this research is to describe the measurement approach, the dataset and the applied architectures considering the software developer's productivity.