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Endoresection of uveal melanoma involves vitrectomy, excision of tumour, retinal-laser under pefluorocarbon liquid (PFCL), PFCLsilicone oil (SO) exchange and cryotherapy to the sclerotomies. Intraoperative pressurised air is avoided as it can enter the bloodstream through vortex veins with potentially fatal pulmonary air embolism [1]. Perfluorodecalin (PFD) has been reported to enter the circulation during endoresection [2], with no systemic complications reported.We describe a case of fatal gas embolism a few hours after endoresection using intraoperative perfluoro-n-octane (PFO) and discuss whether egress of PFO could be causal.

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