This study's primary purpose was to investigate the effects of job demands on in-role performance through the health impairment process among academic leaders at Malaysian Research Universities (MRU)s. The focus was given to both groups' levels (faculties) and individuals' levels (educational leaders). Data were collected via a five-point Likert scale questionnaire emailed to 252 academics at 31 different faculties. Data analysis by utilizing Hierarchical Linear Modeling (HLM) revealed that while the health impairment process is negatively related to in-role performance, job demands from both individuals and group levels are positively associated with the impairment path. By applying the "Monte Carlo Mediation Test; MCMT" in the mediating pathways, the results revealed that the mediation affects academics' impairment health among the relation of individual/group demands and academic leaders' in-role performance. This research indicates that individual conditions influence academic performance, and the group's shared perception has a substantial role. In turn, decision-makers would gain a comprehensive understanding of potential factors that may impact educational leaders' well-being and performance and strive to improve them in a way that develops MRUs.