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Background: Osteopontin expression is increased in numerous diseases with underlying increases in H 2 O 2 . Results: H 2 O 2 -dependent osteopontin expression is biphasic. Early increases occur through translation via redox-dependent 4EPB-1, whereas late increases require NF-B-and AP-1-dependent transcription. Conclusion: H 2 O 2 -induced osteopontin expression is both translational and transcriptional. Significance: Understanding how osteopontin is regulated is critical for targeting this inflammatory protein in H 2 O 2 -dependent pathologies.