S creening for ADME/Tox properties of compounds is a key step in the drug development process. Three applications defining such properties, namely Cytochrome P450 Inhibition, Serum Protein Binding and P-glycoprotein Interaction were developed and the performance of each was evaluated on Tecan's LabCD-ADMET System. The LabCD-ADMET System is an automated platform which integrates microfluidics, in the form of the centrifugally driven LabCD device; liquid handling and assay robotics, in the form of a modified GENESIS liquid handling workstation; an incubation, spinner, and detection system, the ULTRA LabCD; and platform/application-specific software. The assay approach and the data for each application are presented. Two applications, Cytochrome P450 inhibition and serum protein binding assays, have also been externally validated at leading pharmaceutical companies within Tecan's Early Access Program (EAP). The LabCD-ADMET System provides a miniaturized, integrated, and automated turnkey solution for various ADME/Tox applications. Assay Approach Automation: The miniaturized assays presented here use the LabCD-ADMET System (Figure 1). This system integrates the centrifugally driven microfluidic LabCD (Figure 2 & 3), an Ultra LabCD/microplate reader, and software on the Genesis robotic platform.

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The Cook Inlet Information Management/Monitoring System (CIIMMS) provides an interactive website that links to a geographically distributed system of information providers. Through the CIIMMS website, users are able to identify and access (e.g., download and print) information ranging from primary data (geospatial and tabular) to reports, project descriptions, and other documents across a variety of themes, such as habitat, land use, resource management, pollution, and water-quality information. CIIMMS will also provide (on-line) tools to make it easy to contribute information to the CIIMMS network. In the long term, CIIMMS will use integrated information resources and tools to create a virtual community center for Cook Inlet learning, resource management, and related activities.CIIMMS not only comprises the hardware, software, and information contact components of the Cook Inlet information management system; it also establishes a framework for managing information resources more efficiently. Two important components of CIIMMS development are (1) establish an advisory group made up of data providers and users to oversee implementation and (2) publish guidelines on how to implement various aspects of the framework (e.g., compile metadata). By providing the tools and the framework that enable a unified approach to information management throughout the watershed, CIIMMS will help agencies and organizations use existing resources more effectively.

Familial hypercholesterolemia (FH) is a monogenic disease characterized by a lifelong exposure to high LDL-C levels that can lead to early onset coronary heart disease (CHD). The main causes of FH identified to date include loss-of-function mutations in LDLR or APOB, or gain-of-function mutations in PCSK9. Early diagnosis and genetic testing of FH suspects is critical for improved prognosis of affected individuals as lipid lowering treatments are effective in preventing CHD related morbidity and mortality.In the present manuscript, we developed a comprehensive next generation sequencing (NGS) panel which we applied on two different resources of FH in the Icelandic population: 62 subjects from 23 FH families with known or unknown culprit mutations, and a population-based sampling of 315 subjects selected for total cholesterol levels above the 95 th percentile cut-point. The application of the NGS panel revealed significant diagnostic yields in identifying pathogenic LDLR mutations in both family and populationbased genetic testing.