No abstract

Chronic pain, or pain that lasts longer than 3 months, is prevalent in the palliative care population. The overall approach involves adherence to a comprehensive plan of care, optimally driven by a single primary provider. For the emergency clinician, the initial assessment focuses on the functional impact of the pain complaint and identifying any new component of the complaint that might indicate an immediate threat to life or limb. Improvement is a long-term goal, best coordinated with the primary provider whenever possible. Opioids may play a role in managing chronic pain if associated with overall functional improvement. Adjuvant therapies, both nonpharmacological and pharmacological, also play an important role in the comprehensive plan of care.

No abstract

alpha-Azido -Azido acylals are a novel combination of azide (N3) and acylal [R-C(OOCR)2] functional groups. Since these compounds are new chemical entities, little is known in the chemical literature about their physical, chemical, and biological properties. This synthetic methodology investigation sought to (1) develop a one-pot, two reaction method for preparing alpha-azido acylals and (2) investigate the chemical reactivity of alpha-azido acylals with phosphine reagents. Progress has been made and will be discussed regarding both the synthesis and reactivity of alpha-azido acylals. This work developed methods and processes that will have significant impact in our broader objective of exploring the reactivity and determining the synthetic usefulness of novel alpha-functionalized acylals.