This research is aimed to look at the existing literature on the effects of photobiomodulation (PBM) on a variety of medical illnesses with a high severity rate. Photobiomodulation, also known as non-thermal laser treatment, is an approaching field in the technology of medicine that involves exposing tissues to precise wavelengths of light to generate therapeutic effects. Photomedicine is based on the outcomes of coherent and noncoherent visible light on cells and tissues, like low-level lasers and light-emitting diodes (LEDs). This therapy method has an impact on cell function, proliferation, and migration, as well as tissue regeneration. Thus, this therapy's mechanism is particularly effective in displaying favorable benefits in neurological, pulmonary, inflammatory, dermatological, and wound healing illnesses and oncology. Using the biphasic dose-response technique, each ailment is addressed with a specific type of laser and within a defined wavelength range to produce the required effect of the therapy.