Background: Neither a vaccine nor specific therapeutic drugs against 2019 novel coronavirus have been developed. Some studies have shown that Xuebijing injection (XBJ) can exert an anti-inflammatory effect by inhibiting the production of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and other cytokines.This study aimed to investigate the effect of XBJ on coronavirus disease 2019 (COVID-19) and its effects on IL-6 and tumor necrosis alpha TNF-α.Methods: A total of 42 patients, who were diagnosed with COVID-19 and treated with XBJ combined with routine treatment at Chongqing University Three Gorges Hospital between January 20, 2020, and March 11, 2020, were selected as the observation group. A control group comprising 16 patients who received routine treatment was also established, and cases were matched from the observation group on a 1:1 basis according to age, comorbidities, and mild and severe disease. The clinical symptoms, laboratory test indexes, and changes in computed tomography (CT) scans of patients in the two groups were observed at the time of admission and 7 days after treatment, and the time taken for the patients to produce a negative nucleic acid test was also recorded.Results: There were no significant differences in baseline data between the two groups. After treatment, there were significant improvements in IL-6 levels and body temperature in the observation group as compared with the control group. Particularly in severe patients, the reduction in body temperature in the observation group was greater than that in the control group (P<0.05). A higher number of patients in the observation group showed improved CT imaging results compared with the control group, and the time taken to produce a negative nucleic acid test was shorter in the observation group than in the control group;

Objective To investigate the expression of nuclear actor-k-gene binding(NF-κB) and immediate early response 3(IER3) in nuclear factor-activated B cells in ovarian endometrioid cysts. To analyze the correlation between the expression of NF-κB and IER3 and the recurrence of the ovarian endometrioid cyst. Methods From January 2018 to March 2019, a total of 80 patients who underwent laparoscopic ovarian cyst excision due to ovarian endometrioid cyst in the Department of Gynecology, Changzhou Maternal and Child Health Hospital were selected, including 40 patients without postoperative recurrence and 40 patients with recurrence, and the patients with recurrence were further divided into the primary recurrence and the secondary recurrence groups. The general clinical data of the patients were collected. The patient's Revised American Fertility Society (R-AFS) score, least function(LF) score, and endometriosis fertility index (EFI) were calculated, and immunohistochemical staining was performed to detect the expression of IER3 and NF-κB in the pathological tissues of the three groups. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of IER3 and NF-κB expression on postoperative recurrence of the ovarian endometrioid cyst. Cox proportional hazards model was fitted to analyze the related influencing factors of ovarian endometrioid cyst recurrence. Results The expression intensity of NF-κB was positively correlated with IER3 (P < 0.001). ROC curve showed that the area under curve (AUC) of NF-κB and IER3 combined diagnosis was 0.844, 95%CI was 0.754–0.933, sensitivity was 77.5% and specificity was 90.00%. Multivariate Cox survival regression showed that the IER3 expression intensity > 4.5 (HR = 4.661,95%CI: 1.712–12.690, P = 0.003) and the NF-κBexpression intensity > 4.5 (HR = 2.878,95%CI: 1.181–7.011, P = 0.020) were independent risk factor for postoperative recurrence, and EFI score (HR = 1.289,95%CI: 1.037–1.602, P = 0.022) was a protective factor for postoperative recurrence. Conclusion EFI score is a protective factor for postoperative recurrence, and the expression intensity of NF-κB and IER3 has a certain correlation with the recurrence of ovarian endometrioid cysts. The expression levels of NF-κB and IER3 > 4.5 are independent risk factors for postoperative recurrence.

Objective To investigate the expression of nuclear actor-k-gene binding(NF-κB) and immediate early response 3(IER3) in nuclear factor-activated B cells in ovarian endometrioid cysts. To analyze the correlation between the expression of NF-κB and IER3 and the recurrence of the ovarian endometrioid cyst. Methods From January 2018 to March 2019, a total of 80 patients who underwent laparoscopic ovarian cyst excision due to ovarian endometrioid cyst in the Department of Gynecology, Changzhou Maternal and Child Health Hospital were selected, including 40 patients without postoperative recurrence and 40 patients with recurrence, and the patients with recurrence were further divided into the primary recurrence and the secondary recurrence groups. The general clinical data of the patients were collected. The patient's Revised American Fertility Society (R-AFS) score, least function(LF) score, and endometriosis fertility index (EFI) were calculated, and immunohistochemical staining was performed to detect the expression of IER3 and NF-κB in the pathological tissues of the three groups. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of IER3 and NF-κB expression on postoperative recurrence of the ovarian endometrioid cyst. Cox proportional hazards model was fitted to analyze the related influencing factors of ovarian endometrioid cyst recurrence. Results The expression intensity of NF-κB was positively correlated with IER3 (P < 0.001). ROC curve showed that the area under curve (AUC) of NF-κB and IER3 combined diagnosis was 0.844, 95%CI was 0.754–0.933, sensitivity was 77.5% and specificity was 90.00%. Multivariate Cox survival regression showed that the IER3 expression intensity > 4.5 (HR = 4.661,95%CI: 1.712–12.690, P = 0.003) and the NF-κBexpression intensity > 4.5 (HR = 2.878,95%CI: 1.181–7.011, P = 0.020) were independent risk factor for postoperative recurrence, and EFI score (HR = 1.289,95%CI: 1.037–1.602, P = 0.022) was a protective factor for postoperative recurrence. Conclusion EFI score is a protective factor for postoperative recurrence, and the expression intensity of NF-κB and IER3 has a certain correlation with the recurrence of ovarian endometrioid cysts. The expression levels of NF-κB and IER3 > 4.5 are independent risk factors for postoperative recurrence.

Background: To investigate the factors associated with postoperative recurrence in patients with ovariantype endometriosis (EMS) who were treated with conservative surgery and to provide ideas for preventing disease recurrence in advance of treatment. Methods:The study included data from 289 inpatients with ovarian-type EMS who underwent conservative laparoscopic surgery in the