A b s t r a c tIntroduction: Brain injury caused by ischaemic stroke is a major cause of disability and death throughout the world. The present study evaluates the neuroprotective effect of pseudopterosin A (PtA) against ischaemia-induced brain injury. Material and methods: Ischaemia was induced by pMCAO model, and rats were separated in to three groups. A control group; an ischemic group receiving saline solution; and a PtA group receiving PtA (5 mg/kg, i.p.) for the period of three days, i.e. two days before surgery and after the surgery. Effect of PtA was assessed by estimating the infract volume and neurological deficits. Level of oxidative stress, inflammatory mediators, and markers of apoptosis were estimated in the brain tissues. Western blot assay and immunohistochemistry was done for the assessment of expressions of protein.Result: Data from the study suggest that treatment with PtA significantly decreases the infracted volume and neurological deficit score compared to the ischaemic group. Treatments with PtA attenuate the activity of antioxidant enzyme, and the level of inflammatory mediators and markers of apoptosis in the brain tissues of ischaemia-induced brain injury. Phosphorylation of FKHR, Bad, and Akt were significantly reduced in the PtA-treated group compared to the ischaemic group.Conclusions: The present study shows that pseudopterosin A attenuates neuronal injury in the pMCAO model by acting on the Akt signalling pathway.

In order to implement the information fusion of electronic products, the widely adopted approach is to extract information from HTML structure of business Website with deeply data processing. However, modeling Web application is hard to be solved that the data in HTML is semi-formal which displayed as DOM (Document Object Model) tree when using XML schema to data analysis. How to understand and extract information is first to be researched. The general model Anchor-Hop considering the text property and label property is simple to handle this problem. Therefore, it has low effectiveness. This model is sensitive to the data of HTML structure, that if the website structure is slightly changed the issue of extraction accuracy is encountered. As a result, the extraction rules should be redefined because of the changed structure. In order to improve extraction efficiency, this paper proposed a DOMbased dynamic model Anchor-Hop-T information extraction model. The HTML tags including table, ol and ul can be searched and processed using XPath so that it is convenience to extract corresponding Anchor data block. Furthermore, the location of Hop point is considered as invariant, by which our new model based on Anchor and Hop point introduces more concepts for extracting information, such as Anchor data block, Anchor locating library and AH relevance value. Finally, we try to give out an experiment to demonstrate the applicability of our approach.

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Electronic form system integrates with workflow management system (WFMS) more and more closely nowadays. However, there are still some serious problems existing in the integration, which are as follows: 1) Achieving the aim of correct access control of form elements, 2) Mapping parameters between workflow variable and form elements, and 3) Customizing and reusing the process of form elements to decline the coupling between electronic form system and workflow management system.To resolve the above problems, we propose a new framework, adopting business rule engine as the intermediary to integrate electronic form with workflow management system. This design involves dynamic configuration for the access control of form elements, special parameters mapping combined with business rule engine, and loosely coupled form elements processing.

Steam Generator (SG) is one of the main components of the power cycle in pressurized water reactor (PWR), and it is the hub of primary coolant circuit and secondary circuit, so the thermal hydraulic analysis of the SG is crucial in the system design and safety analysis of the PWR. The horizontal steam generator (HSG) is one of the main types SG in the PWR nuclear power plant (NPP), and its advantages are that it has more secondary side water capacity and good safety and reliability. The VVER-1000 is a PWR with a thermal power of 3000 MW, and has four HSGs for four loops. The RELAP5 has been used to model the VVER-1000’s HSG and performs the analysis described in this paper. The HSG tube bundle is modeled by three horizontal channels, and the steam control volumes above the heat transfer tube bundle are modeled with three volumes. The steam space is modeled as a steam separator and the steam reception shield is the dryer. The HSG secondary side downcomers are represented with a separate component to provide the power of the natural circulation. To verify the accuracy of the model, three different typical conditions are simulated. The simulation results show that the model built in this paper can correctly simulate the operation of the HSG in VVER-1000.