A copper-catalysed coupling of bromo-alkynes and organic azides is described. This coupling results in the formation of bromo-containing trisubstituted 1,2,3-triazole derivatives in high yield and a regioselective manner.

Triazole derivatives R 0280Copper (I)-Mediated Synthesis of Trisubstituted 1,2,3-Triazoles. -The Cu(I)-catalyzed 1,3-dipolar cycloaddition of organic azides with bromoalkynes results in formation of 1,2,3-triazoles in a regioselective manner. -(KUIJPERS, B. H. M.; DIJKMANS, G. C. T.; GROOTHUYS, S.; QUAEDFLIEG, P. J. L. M.; BLAAUW, R. H.; VAN DELFT, F. L.; RUTJES*, F. P. J. T.; Synlett 2005, 20, 3059-3062; Inst. Mol. Mater., Radboud Univ. Nijmegen, NL-6525 ED Nijmegen, Neth.; Eng.) -Mais 17-131