Background Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are devastating clinical disorders with high mortality, and for which more effective therapies are urgently needed. FGF1, the prototype member of the FGF family, is shown to exert protective effects against injurious stimuli in multiple disease models. Here we aimed to evaluate whether FGF1 pretreatment is protective against LPS-induced ALI and elucidate the potential underlying mechanisms. Methods For drug-treated groups, C57B/6 mice received a single i.p. injection of FGF1 (1 mg/kg) 1 h before the LPS challenge or not. To induce the ALI model, the mice were treated by intratracheal instillation of LPS (5 mg/kg). Then, histopathological changes in lung tissues were assessed by hematoxylin and eosin staining and transmission electron microscopy. ELISA and qPCR assays were used to detect pro-inflammatory cytokine levels in BALF and lung tissues, respectively. The total number of inflammatory cells (neutrophils and macrophages) in BALF were counted using the Wright-Giemsa method. The expressions of reactive oxygen species (ROS) and malondialdehyde (MDA) were measured using their respective kits. Western blot and immunostaining were used to evaluate the expressions of antioxidants (Nrf-2, HO-1, SOD2, GPX4, and Catalase), as well as the inflammatory and/or apoptosis-related factors (TLR4, NF-κB, and Cleaved- caspase 3). Results FGF1 pretreatment significantly ameliorated the LPS-induced histopathological changes, reduced lung wet/dry ratios, ROS and MDA levels, total BALF protein, inflammatory cell infiltration, proinflammatory cytokine levels, and significantly increased the expression of antioxidant proteins (Nrf-2, HO-1, Catalase, and SOD2). In addition, FGF1 pretreatment significantly reduced the expression of TLR4 and cleaved- caspase 3, inhibited NF-κB activation, and reduced LPS-induced cell apoptosis. Conclusions Altogether, our results suggest that FGF1 pretreatment is protective against LPS-induced ALI through mediating anti-inflammatory and antioxidant effects, which may be attributed to the downregulation of TLR4 expression and inhibition of NF-κB activation, as well as promotion of antioxidant defenses. Therefore, FGF1 administration may prove beneficial in preventative strategies for ALI/ARDS.

Non-small cell lung cancer (NSCLC) accounts for over 80% of all cases of lung cancer, a leading cause of cancer-related death worldwide. NSCLC patients frequently harbour activating mutations in the epidermal growth factor receptor (EGFR) gene, particularly in the first four exons (exons 18-21) of the EGFR tyrosine kinase domain, which is strikingly high in East Asian populations. 1 EGFR signalling plays a pivotal role in cellular proliferation, survival and metastatic progression, as well as chemoresistance. 2

Background In recent years, china has paid more and more attention to the status and role of parenting style in the whole education system, and clearly proposed to “Give full play to the important role of family education in the growth of teenagers” In the national long-term education reform and development plan (2010-2020). The junior middle school stage is more important in the whole development process of middle school students, and junior middle school students are in puberty. At this stage, their rapid physical development and intense emotional fluctuations are the “Storm” of emotional development. After all, the education of emotional regulation ability infiltrated by school education and teaching in students' mental health education is limited, there is also a lack of corresponding guidance on whether students can master effective methods of emotional regulation, or some schools have not attracted attention. As the first caregiver of children, the influence of parents on students directly determines their relationship with others and their own management. In this special stage of junior middle school, students want to try their best to get rid of the control of their parents and let their parents treat themselves as “Adults”. Parents still treat them as “Children” As always. This huge contradiction determines that the parenting methods and methods of parents in their children's study and life will also have an impact on their children, thus affecting their emotional regulation. Because of these, this study aims to explore the relationship between parenting style, interpersonal skills and emotional regulation of junior middle school students with hearing impairment in southern minority areas. Subjects and Methods 123valid questionnaires were collected from several representative special schools. Taking the hearing impaired junior middle school students in special education schools in southern minority areas such as nanning, guilin, liuzhou and qinzhou as the main research object, the investigation was conducted through online electronic questionnaire. This study draws on the research results of scholars at home and abroad, and based on the existing relevant theories. The chinese version of the emotional regulation scale (revised by ji junmei (2009) and the chinese version of the chinese version of the chinese version of the chinese version of the chinese version of the chinese version of the emotional regulation scale (pbi) (revised by ji junmei (2010) and yang jiamei) 0 for descriptive analysis, analysis of variance and linear regression analysis. Results The rearing style of hearing-impaired junior middle school students tended to be negative. There were significant differences between men and women in father overprotection. The father overprotection of boys was significantly higher than that of girls; there are significant gender differences in interpersonal communication ability in conflict resolution ability, and boys are significantly better than girls in conflict resolution ability; there are significant differences in self disclosure ability in grades, showing an upward phenomenon in grades; the non only child is significantly better than the only child in moderate rejection ability. The emotional support ability of junior middle school students with hearing impairment in interpersonal communication is significantly stronger than that of single parent families. Conclusion There is a significant positive correlation between the rearing style and interpersonal communication ability of hearing impaired students in junior middle school, in which the emotional warmth of the mother is positively correlated with the ability of interpersonal relationship establishment and conflict resolution, and the refusal and overprotection of the mother are positively correlated with the ability of self disclosure. In terms of emotional ability, there is no difference between men and women, but there is a grade difference, and the third grade is significantly higher than the second grade; there is a significant negative correlation between the emotion regulation ability of junior middle school students and parental care. The more parents care for their children, the less their children's bad emotions will be; there is a significant positive correlation between junior middle school students' bad emotions and parental control. The more parents control their children, the higher the children's bad emotions will be. Parental care, parental encouragement and parental control can significantly predict children's emotional regulation ability; parental care and encouraging autonomy were significantly positive predictors, and parental control had a negative predictive effect on emotional regulation. Acknowledgements The authors acknowledge the project of Guangxi department of education: Research on the construction of early intervention support system for special children aged 3-6 in Guangxi (No.: 2020KY09008); study on the construction of psychological support system for sibling relationship of special children (No.: 2019KY0420) and general research project of humanities and social sciences of the ministry of education in 2021: Research on the strategy of improving the professional quality of county special education teachers in the western region in the new development stage(No.: 21YJA880046); the project of Guangxi department of education in 2022: Research and practice on the “compound” excellent special education teachers training based on the OBE concept.

Abstract-This paper took the authorized patent of geographical indications industry of Chinese herbal medicine as the research object, through the analysis of the types of the industry patent, technical category, legal status, maintenance information, found that the geographical indications of Chinese herbal medicine industry patents have mainly focused on design patents, technical patents, especially the invention of the proportion of patents less. Overall, the current number of geographical indications of Chinese herbal medicine industry is very limited, and the quality of patents at a low level in China.

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