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Inflammation plays a pivotal role in temporal lobe epilepsy (TLE) pathophysiology. IL-33 can act as a transcription factor or as a cytokine, the latter through the transmembrane ST2 receptor or its soluble isoform (sST2), presenting a dual role in neurological diseases. The aim of this study was to determine the plasma levels of IL-33 and sST2 in parallel with clinical features in patients with TLE. Peripheral blood from patients and controls was sampled for the measurement of plasma levels of IL-33 and sST2 by enzyme-linked immunoassay (ELISA). While there were similar levels of IL-33 between controls and patients, sST2 were increased in patients. IL33 and sST2 plasma levels were not associated with TLE-related clinical features. In a subgroup analysis, IL-33 levels correlated with memory performance. In conclusion, our results reinforce the concept of chronic low-grade inflammation in patients with TLE.

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Introdução e objetivo:Alterações na composição corporal podem influenciar na funcionalidade dos idosos. Sendo assim, o objetivo deste estudo foi mensurar o estado nutricional e a força de preensão palmar em idosos fisicamente ativos, praticantes da modalidade ritmo. Materiais e métodos: A amostra foi composta por 31 idosas, a composição corporal foi mensurada através da bioimpedância elétrica tetrapolar e a força de preensão palmar pelo dinamômetro Jamar. As análises foram conduzidas em grupos de idades diferentes (≤ 68 e > 68 anos) e entre os indivíduos com índice de massa muscular adequada (IMMa > 6,75 kg/m 2 ) e insuficiente (IMMi ≤ 6,75 kg/m 2 ). As diferenças entre os grupos foram realizadas a partir do teste t de Student, para amostras independentes, e as correlações a partir do teste de Pearson. Resultado e conclusão: A composição corporal indicou que 43,8% das idosas possuíam gordura corporal excessiva e 64% massa muscular adequada. Observou-se que aquelas com idade superior a 68 anos apresentavam redução estatisticamente significante na massa corporal (p = 0,014) e no IMC (p = 0,025). A força de preensão palmar foi considerada adequada em 77%, quando avaliado o membro direito, e em 99% para o membro esquerdo. Não foram identificadas correlações entre as variáveis força e composição corporal. Concluiu-se que as mulheres avaliadas possuíam força adequada e massa magra satisfatória, em sua grande maioria, porém apresentavam percentual de massa gorda desfavorável, fazendo-se necessárias intervenções direcionadas à mudança do perfil de adiposidade nessa amostra.Palavras-chave: Composição corporal; força da mão; idoso. ■ ABSTRACT Introduction and objectives:Changes in body composition may interfere in the physical functionality of elderly. The objective of this study is to measure the nutritional state and the handgrip strength in physically active elderlies who practice rhythm activity. Materials and methods: The sample was composed of 31 elderly women; the body composition was measured by tetrapolar electrical bioimpedance and the handgrip strength was measured by Jamar dynamometer. The analyses were performed in groups of women with different ages (≤ 68 and > 68 years), in those with adequate muscle mass index (IMMa > 6.75 kg/m 2 ) and in those with insufficient muscle mass index (IMMi ≤ 6.75 kg/m 2 ). The differences between the groups were measured by Student's t-test, for independent samples, while the correlations were measured by the Pearson's test. Results and conclusion: Body composition has showed that 43.8% of elderly had excessive body fat and 64% had adequate muscle mass. Those older than 68 years old have showed significant reduction of body mass (p = 0.014) and of body mass index (BMI, p = 0.025). The handgrip strength was considered adequate in 77%, regarding the right member, and in 99% when considering the left member. Correlations between handgrip strength and body composition have not been identified. Finally, it was concluded that the analyzed women had adequate handgrip strength and sati...