No abstract

1,3,4,6‐Tetrachloro (TCDGU) and 1,3,4,6‐tetrabromo‐3α,6α‐diphenylglycolurils smooth halogen oxidizers have been exploited in a new direction as reagents for free radical substitution toward some N‐halosuccinimide nonreactive bis‐heterocycles. An unexpected selectivity and reactivity were observed with methyl benzenes, methyl heterocycles, and methyl‐bis‐heterocycles of interest. A chemometric study has been performed to optimize five independent factors of the chlorination reaction with TCDGU. The predictive model was established either for the halogenation conversion and the ratio of monochlorination.

The synthesis of C3-symmetrical tris-(ACE)-(6,6'-bis-heterocyclyl)-α-cyclodextrins via"one pot" Staudinger-Aza-Wittig (SAW) reaction is described. The spectroscopic properties of their metal coordination compounds were analysed. The spontaneous formation of metallosupramolecular helicates generate strong exciton coupling features enlighten much information on the nature, the geometries of the complexes and their absolute configuration.