Some Ameloblastomas are benign but turn out to be recurrent tumors, the importance of which lies in their potential to grow to enormous size with consequent bone deformity. At the level of reconstructive options for mandibular continuity defects produced by these entities, the use of free microvascular flaps, free bone graft and alloplastic implants, including titanium reconstruction plates and titanium trays, have been considered. In this article we will develop the situation of a 30-year-old patient who suffered from a multicysti came loblastoma that was resected with a safety margin and personalized 3D titanium prosthesis was made.