Pyogenic granuloma (PG) is a well known oral lesion which occurs as response of tissue to chronic lowgrade irrititation, traumatic injury, hormonal factors and some drugs. PG occurs cosmetic deformity, recurrent hemorrhage, and functional problems in speaking, swallowing and chewing. Beside this, oral melanin pigmentation on gingiva may cause esthetic problem. A 28-year old female applied to our clinic with nodular gingival enlargement in the maxillary gingiva on the vestibular surface of the right central and lateral incisors. Also she complained from gingival hyperpigmentation in her mandibular and maxillar gingival region. In this case report, we presented the use of surgical Nd:YAG lasers for gingivectomy of soft mass and depigmentation of vestibular gingiva without any complication. Treatment with laser presents minimal postoperative problems, discomfort and scarring.