Objective: The aim of the current study is to evaluate the effect of pterostilbene (PTS), on deranged plasma and tissue glycoprotein components in high-fat-diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice. Methods: The experimental duration was 16 weeks. The C57BL6/J mice were fed a normal diet, normal diet with PTS, HFD, and STZ injection (10th week only), and diabetic mice with PTS for the past 6 weeks. Results: A significant increase in glycoprotein components such as hexose, hexosamine, fucose, and sialic acid (SA) in plasma was observed in diabetic mice. In hepatic and renal tissues, a significant decrease in SA with an increase in other glycoprotein components was detected in diabetic mice when compared with control mice. Oral administration of PTS significantly improved the glycoprotein levels in plasma and tissues of diabetic mice to near normal level. Conclusion: In this study, we resolved that PTS improves disturbed glycoprotein metabolism in HFD and STZ-induced type 2 diabetic mice.

ABSTRACT Objective: To investigate the effect of valencene on dearrangement in glycoprotein levels in the streptozotocin(STZ)-nicotinamide(NA)induced diabetic rats. Materials and Methods: Diabetes was induced in experimental rats by a single intraperitoneal (i.p) injection of STZ (45 mg/kg b.w) dissolved in 0.1 M citrate buffer (pH 4.5) 15 minutes after the i.p injection of NA (110 mg/kg b.w). The levels of glycoproteins were altered in experimental diabetes mellitus. Valencene were administered to diabetic rats intragastrically at 100 & 200mg/kg bw for 30days. The effects of valencene on plasma glucose, insulin, plasma and tissue glycoproteins were studied. Results: Oral administration of valencene (200mg/kg b.w)for 30d, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. The levels of plasma glucose were decreased with significant increase of plasma insulin level. The altered levels of plasma and tissue glycoprotein components were restored to near normal. Conclusions: The results of the present study show the potent beneficial effects of valencene in modifying the levels of glycoprotein components in plasma and tissues of diabetic rats.

Objective: Diabetes is a metabolic disorder characterized by enhanced production of free radicals hence oxidative stress. The aim of this study was to evaluate the activity of cardiac and antioxidant enzymes in high-fat diet-fed and streptozotocin-induced type 2 diabetic mice.The experimental study period was 16 weeks. Material and methods: C57BL6/J mice were fed a normal diet, normal diet with Pterostilbene (PTS), high-fat diet (HFD) and streptozotocin injection (10 week only), diabetic mice with PTS for last 6 weeks. Diabetic mice had high level of cardiac total th cholesterol, triglycerides and free fatty acids level.Cardiac markers such as AST, CK-MB Results and conclusion: and LDH levels were significantly increased in diabetic mice. The activity level of enzymic (SOD, CAT and GPx) and non-enzymic antioxidant (Vitamin C, E and GSH) were lower diabetic mice. The levels of lipid peroxidation markers significantly increased in heart tissues. Treatment with PTS at a dose of 40mg/Kg BW significantly improved the parameters. This study suggests that PTS could be effective in improving cardiac dyslipidemia and antioxidant status in type 2 diabetes.