Rapid incremental urbanization in China has resulted in an incomplete modern infrastructure system and multiple point-like flaws. This is due to a lack of funding and poor scientific construction concepts and procedures. This also contributes to the infrastructure system’s low disaster-adapted resilience and insufficient coupling coordination of production-oriented and service-oriented infrastructure subsystems. Based on the “Robustness-Rapidity-Redundancy-Resourcefulness-Durability” (4R-D) frameworks, this study screens 53 indicators across three tiers of “production-oriented, service-oriented, intelligent” infrastructure subsystems to establish a modern infrastructure resilience evaluation system. We examined the overall infrastructure resilience and coupling coordination development among subsystems in the Three Gorges Reservoir Area (TGRA) from 2009 to 2020 using a coupling coordination degree model (CCDM). Grey relational analysis (GRA) was used to analyze the significant control aspects of infrastructure resilience and coupling coordination degree based on grey system theory. The findings show the following: (1) at the macro level the overall resilience, resilience of each subsystem, and coupling coordination among subsystems in the research region show an upward trend from 2009 to 2020, with the rise from 2018 to 2020 being the most significant; (2) at the micro level, from 2010 to 2013, there was no obvious spatial divergence and from 2014 to 2020, driven by the radiation of the two major urban agglomerations, the resilience and coupling coordination of Yiling and Wanzhou both show a trend of more substantial increase, while the rest of the counties have a small increase; and (3) at the meso level, seven factors have a more significant impact on the coupled and coordinated development of urban infrastructure than other indicators, including urbanization rate, average annual rainfall, the number of health technicians per 10,000 people, and the percentage of GDP in the tertiary industrial sector.

Due to a lack of guidance in urban systems thinking, China’s rapid urbanization has intensified the interactions and coercive effects between the various urban space subsystems. As a result, “urban diseases” such as environmental pollution, frequent earthquakes, and unbalanced urban–rural development have spread. As a complex giant system, the exploration of urban resilience enhancement is critical to ensuring the joint spatial development of cities and towns. Based on the PSR model, this study screens 38 indicators in five levels of the natural-material-economic-social-intelligent regulation subsystem of the Three Gorges Reservoir Area urban giant system, and constructs a multi-source data resilience assessment framework. Likewise, it employs the Geodetector model to investigate the key factors impacting the resilience mechanism. The results demonstrate that: (1) between 2011 and 2020, the overall resilience in the Hubei section of the Three Gorges Reservoir Area increased from low to high and the coupled characterization of the “pressure-state-response” increased at different rates, with the state layer increasing the most; (2) the frequency of geological hazards, urbanization rate, and total number of early warning and monitoring of geological hazards are the key factors that contribute to changes in spatial resilience; (3) enhanced resilience is the result of the synergistic effects of different driving factors. Our model is used to assess the resilience of the urban system, assisting decision-makers in planning strategies to respond to urban system problems effectively and improve urban resilience.