A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.

Three new dioxopiperazine metabolites (1-3), together with two known compounds, N-acetyltyramine (4) and cyclo-(Ala-Val) (5), were isolated from a marine-derived fungus Aspergillus fumigatus Fres. Their structures were established by spectroscopic methods. Their cytotoxic activities against the K562 cell line were preliminarily evaluated by the sulphorhodamine B (SRB) method.