The effective conductivity of a composite containing cylindrical fibers of graded materials has been theoretically investigated. Typical graded profiles were considered and the response to an applied electric field was studied in detail. The effective conductivity of the composites was calculated based on the analytic solution for an isolated graded fiber inclusion in the dilute limit. A composite containing fibers of graded shells was considered, which is a useful model to simulate the effect of a general graded conductivity profile.

In postmenopausal women, obesity, falls, unknown osteoporosis status, and osteoporosis are associated with high risk of distal radius fracture. If comorbidities and advanced age are also present, this group of persons may be at higher risk for unstable distal radius fractures.

PurposeThis study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma.Materials and MethodsLewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed.ResultsFor the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved.ConclusionOur results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.

e digital image correlation method (DICM) has been applied to similar material simulation experiments for rock-like materials, to overcome the weakness of traditional measurements, for example, data discontinuous. In this paper, the movement and fracturing process of the overlying strata during excavation are observed and studied, and the distributions of stress, strain, and deformation in the overlying strata are obtained based on similar material simulation. e DICM is applied to improve the testing method and to optimize the discontinuity of testing points; of course, the difference of rock deformation in the overlying strata during excavation is considered. Full-field deformation and strain are analyzed by the DICM. To verify the accuracy of the DICM, results obtained from the DICM, numerical simulation and similar material simulation, are compared. e DICM can reflect the characteristics of locality and randomness of rock-like materials more real than numerical simulation, and comparing with similar material simulation, it can directly reproduce the movement and fracturing process of the overlying strata during full-field excavation. It shows that, the DICM is entirely feasible to using in the large scale full-field deformation measurement on complex rock structure, and it is of theoretical importance for testing for rock-like materials.

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