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Obesity has become one of the most important health problems worldwide requiring urgent need for efficient control. Pleurotus citrinopileatus ( P. citrinopileatus )—a type of edible mushroom with abundant bioactive molecules—is a promising source for achieving this goal. In the present study, we evaluated the anti‐obesity and hypolipidemic effect of P. citrinopileatus water extract ( PWE ) using a series of biochemical assays in randomized high‐fat diet‐induced obese ( DIO ) C57 BL /6J mice, which were gavaged daily with low or high levels of PWE (400 or 800 mg/kg of body weight, respectively) in addition to high‐fat diet for 12 weeks. Results showed that PWE significantly reduced the weight gain, fat accumulation, and food intake of DIO mice within 12 weeks. PWE also decreased the serum triglycerides, cholesterol and low‐density lipoprotein, aspartate transaminase, nonesterified fatty acid, and creatinine, but increased high‐density lipoprotein. Additionally, PWE improved the glucose tolerance of mice fed with high fat. From above, we conclude that PWE has great potential as functional foods for management of obesity and/or associated metabolic disorders.

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