Amides are one of the most ubiquitous and important functional groups in natural products and synthetic drugs. The research of forming methods for amide is of great significance, also it is now a hotspot in the research of the synthetic method. Herein, the synthetic methods of amides in recent years are reviewed, which is of great significance for future research.

The reductant zinc powder and the oxidant sodium chlorate were used together in an appropriate ratio in one pot under ambient conditions, to provide an environmentally friendly, effective, and convenient method for the synthesis of aromatic amides in good yields from nitroarenes and aldehydes in the green solvents alcohol and water under atmospheric conditions. The good results indicate that reductants and oxidants with opposing properties can not only be used together without any adverse effects, but also improve the reaction yield through their cooperation.

Aldehydes. -(SHENG, G.; WU, X.; CAI, X.; ZHANG*, W.; Synthesis 47 (2015) 7, 949-954, http://dx.