Amlodipine is a calcium channel blockers and belongs to class Dihydropyridines and used to reduce systemic vascular resistance and arterial pressure. Nevertheless, they remain the major case of cardiovascular drug overdose that often leads to lethal outcome. We report the case of intoxication with Amlodipine. This caused severe hypotension, in young health care worker. Patient was initially treated in our ICU with leg and elevation, fluids, calcium gluconate, noradrenaline, glucagon.