Morbidity and mortality due to OP poisoning is directly proportional to the age, severity of poisoning and duration of mechanical ventilation and inversely proportional to serum cholinesterase level.

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BACKGROUND The addition of local anaesthetics with adjuvants improves the efcacy of subarachnoid block. The most commonly used drugs are opioids and newer drugs like dexmedetomidine said to be safer and effective spinal adjuvant. To compare and evaluate sensory , motor blockade and haemodynamic effects between dexmedetomidine -AIMS & OBJECTIVES bupivacaine and buprenorphine - bupivacaine groups. A prospective randomised study was conducted on 60 patients posted forMETHODS elective lower abdominal and lower limb surgeries belonging to ASA 1 & 2 grade. Patients were randomly divided into 2 groups, each group containing 30 patients. Group D receives 3ml (15mg) of 0.5% hyperbaric bupivacaine with 5 mcg dexmedetomidine in 0.5 ml NS while group B receives 3ml (15mg) of 0.5% hyperbaric bupivacaine with buprenorphine 75 mcg in 0.5 ml NS. Sensory , motor blockade and haemodynamic effects were recorded between two groups. There was no signicant difference between two groups regarding demographic data andRESULTS duration of surgery. The rapid onset of sensory block and prolonged duration of sensory and motor blockade achieved with 5μg of dexmedetomidine combined with bupivacaine for spinal anaesthesia suggests that the drug is useful in surgeries requiring prompt onset.