p ‐Phenylazobenzoyl chloride product: p ‐Phenylazobenzoyl chloride (azoyl chloride)

All possible "nonadjacent" phenyltriazolepropionic acids were synthesized and tested for antiinflammatory activity. Two of the isomers displayed activity approximately equal to phenylbutazone: the 4-phenyl-1,2,3,-triazole-2-propionic acid (7) and its reverse counterpart, 2-phenyl-1,2,3-triazole-4-propionic acid (6). The other five isomers were inactive. Since these seven acids are geometrically congruent and possess similar lipophilic characters, antiinflammatory activity must depend on some property that is a function of how the carbon and nitrogen atoms are arranged in the triazole ring.

No abstract

1‐ n ‐Butylpyrrolidine product: 1‐ n ‐butylpyrrolidine

Die Phenyltriazolpropionsäuren (V), (VIII), (XI), (XIII), (XVI), (XX) und (XXII) werden entsprechend dem Formelschema hergestellt.