Introduction: Graft-versus-host disease (GVHD) is a systemic complication that can affect patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and the mouth is one of the places affected by the disease (oGVHD). Topical corticosteroids are used to control the painful symptoms, causing a local immunosuppression and increasing the risk for opportunistic infections.Objective: This study aims to report a case of a 42-year-old woman, diagnosed with Chronic Myeloid Leukemia, who developed oGVHD and herpes simplex virus (HSV) infection after HSCT. Case Report: oGVHD was confirmed by incisional biopsy and viral infection by HSV types 1 and 2 was confirmed by PCR. Topical and systemic corticotherapy and antiviral therapies were instituted. The immunosuppression intensified viral infection and antimicrobial photodynamic therapy (aPDT) was instituted as an adjuvant treatment. aPDT application, along with the patient's immune recovery, antivirals and corticosteroids resulted in clinical improvement of oral lesions. Final Considerations: This study highlights aPDT as an effective adjunct therapy in the local treatment of opportunistic infections in onco-hematological patients.

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2) , João Hormigo (3) (1) bimTEC, Porto (2) bimTEC, Porto (3) EDP Global Solutions, Lisboa Resumo A digitalização de processos é uma diretiva cada vez mais presente e transversal nas empresas de grande dimensão. No caso do Grupo EDP, esta estratégia estende-se à empresa do grupo responsável pela gestão do parque imobiliário, a EDP Global Solutions, que encontrou na metodologia BIM a melhor forma de acelerar o processo de digitalização, através da criação de modelos de informação (BIM) em que seja possível intersetar os benefícios da utilização de interfaces gráficas tridimensionais para centralização e consulta paramétrica da informação de projeto, obra e exploração dos ativos de modo a desbloquear um conjunto de aplicações de processamento de meta-dados para otimização da gestão interna dos ativos imobiliários. O presente artigo descreve a estratégia de digitalização do parque imobiliário da EDP Global Solutions, atualmente em desenvolvimento com o apoio da empresa consultora bimTEC segundo os três vetores operacionais seguintes: 1) preparação de equipa interna para gerir processos BIM envolvendo as empresas prestadoras de serviços; 2) criação dos ativos digitais do parque imobiliário da empresa através da compilação, centralização e modelação BIM da informação dos edifícios; 3) preparação estratégica da infraestrutura necessária para obtenção do gémeo digital dos edifícios.

Introduction: Candida colliculosa is a yeast of food origin classified as Non-Albicans Candida (NAC), with its pathogenic potential confirmed, but little known. Like other opportunistic infections, diseases caused by NAC species are most commonly found in immunosuppressed patients. Objectives: The objective of this work is to report the case of a pediatric patient who developed an atypical lesion associated with Candida collicu- losa in the mouth. Case report: A 9-year-old boy under chemotherapeutic treatment for Acute Myeloid Leukemia developed edema in the lower lip, with a persistent crusted ulcer circumscribed by an erythematous, painless, and progressing negatively. He was using antibiotics, antifungals, antiemetics, and antihistamines. Results: It was decided to perform complementary exams for final diagnosis. Cell smears were collected for exfolia- tive cytology, direct mycological, bacterial and viral culture, and fungi investigation. No viruses and bacteria were identified. A direct mycological examination showed yeast cells without pseudohyphae and a Maldi-TOF technique confirmed the diagnosis of Candida colliculosa. Final considerations: The use of antifungal agents associated with the patient’s immunological recovery led to the complete healing of the lesion and hospital discharge. Identification of the fungal species was important not only to establish the diagnosis and most appropriate treatment but also to avoid the fungus spreading in the hospital environment.