Cross-docking is a logistics strategy in which products arriving at a distribution center are unloaded from inbound trucks and sorted for transfer directly to outbound trucks, reducing costs and storage and product handling times. This paper addresses a cross-docking problem by designing a mixed-integer linear programming (MILP) model to determine a schedule for inbound and outbound trucks in a mixed service-mode dock area that minimizes the time from when the first inbound truck arrives until the last outbound truck departs (makespan). The model is developed using AMPL software with the CPLEX and Gurobi solvers, which provide results for different instances, most of these with actual shift data from an integrated distribution center of a multinational food company located in Concepción, Chile. The results obtained from the case study are notable and show the effectiveness of the proposed mathematical model.