Objective: Obesity is one of the world's leading problems, which is major cause of Cardiovascular Diseases. During COVID -19 pandemic many young children and all age group people are getting challenged by obesity due stagnant life style. To treat such life threatening disorder natural remedies acquire prior position, Plant produce a good deal of secondary metabolites which have a benefited mankind in various ways, including treatment of diseases The present research work was focused on developing a natural remedy using an ancient plant with number of Tamarindus indica, proven activities in Traditional medicine.In the literature survey, it was found that Materials and Methods: flavonoids, sterols, tannins and alkaloids shown promising effects to tackle obesity by various mechanisms, Tamarindus indica has shown the presence of saponins, flavonoids, glycosides, amino acids, alkaloids. With the above evidence, this plant has been selected for screening of its antiobesity activity against high fat diet induced obesity in mice. Studies were conducted using aqueous extract of leaves (AETI) on high fat diet (butter) Tamarindus indica induced model of hyperlipidemia in mice.During 21 days time period AETI low and high Results and Discussion: doses were induced to respective animal groups along with butter where Atorvastatin has been taken as standard drug. Butter enhanced the Cholesterol and triglyceride, LDL levels. At the end of 21 days blood samples were collected from the animal through retroperitoneal route. Biochemical parameters of AETI have been revealed its antiobesity activity.