Left atrial (LA) distension has been demonstrated to be linked with aortic stiffness in different patient populations. Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be a promising tool for volumetric and functional evaluation of the LA. The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects. The study included 19 healthy volunteers (mean age: 37.9 ± 11.4 years, 11 men) who had undergone complete two-dimensional (2D) Doppler transthoracic echocardiography extended with the assessment of aortic elastic properties and 3DSTE. Results: None of LA volumes correlated with echocardiographic aortic elastic properties. Active atrial stroke volume correlated with aortic stiffness index (ASI, r = 0.45, p = 0.05). None of other volume-based functional properties significantly correlated with aortic stiffness parameters. Global peak 3D strain correlated with aortic strain (r = -0.46, p = 0.05). Global radial pre-atrial contraction strain correlated with ASI (r = -0.49, p = 0.04) and AS (r = -0.50, p = 0.04). Conclusions:Correlations exist between 3DSTE-derived LA functional parameters and eschocardiographic aortic elastic properties in healthy subjects.Keywords: aortic, distensibility, echocardiography, function, left atrium, speckle-tracking, stiffness, threedimensionalThere is a strong interplay between vascular and cardiac mechanics including arterialventricular coupling. Left ventricular (LV) remodeling is a powerful determinant of left atrial (LA) size, therefore arterial stiffness could influence LA dimensions, as well (5, 6, 12). Arterial stiffness was found to be associated with LA size in different patient populations (12). Three-dimensional (3D) speckle-tracking echocardiography (STE) seems to be an optimal choice for non-invasive quantification of LV and LA volumes and deformation parameters by 3D volumetric and strain analysis (1,4,7,8,11,13,15,(17)(18)(19)22). The aim of the present study was to determine whether correlations exist between 3DSTE-derived LA volume-based and strain parameters characterizing all phasic functions of the LA and echocardiographic aortic elastic properties in healthy subjects.