The occurrence of a sudden outbreak of agranulocytosis in Finland among patients being treated with clozapine led to intensive investigations in an attempt to find a local precipitating factor. Granulocytopenia after clozapine was found to have the same characteristics as that reported after phenothiazines. No local factor, either genetic or environmental, was found which could have been responsible for the increased frequency of occurrence in Finland. The need to be aware of the risk and to take appropriate precautionary measures (e.g. weekly leucocyte counts in the first months) is emphasized.

In latent diabetes there are easy transitions between normal and pathological values for blood-sugar. In view of the fact that their correct allocation is uncertain, an attempt has been made to calculate the relevant probabilities. Examination of 101 healthy men showed that the corresponding values are practically normally distributed. It is suggested that such normal distribution curves be taken as a basis for the assessment of GTT values.