The aim of this review is to explore the changing utility of radiotherapy in the treatment of patients with glioblastoma over the past decades. Surgery and radiotherapy has always been the cornerstone of treatment of glioblastoma, but techniques have significantly advanced over this time. We selected the main studies that support the advances of radiotherapy in the present day as well as controversies in several aspects of the treatment will be approached; definition of the target volume in the magnetic resonance imaging (MRI) planning, size of the margins around the target volume; prescribed dose (satnadard vs. hypofactionated); management of glioblastoma in elderly; review role of radiosurgery past and new potential use in recurrence and the evidence of reirradiation in patients with local recurrence. Finally, continued development on many fronts have allowed for modestly improved outcomes while at the same time limiting toxicity.

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