Short-term administration of sevoflurane anaesthesia did not induce SCE in T-lymphocytes of children. No indication for a possible genotoxic effect has been observed.

Pyridine derivatives R 0380 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as Novel 5-HT 6 Receptor Agonists. -A series of the title indole derivatives [cf. (VI)] are synthesized and evaluated for their 5-HT6 activity. Compound (VIa) proves to be the most potent agonist in this series. -(MATTSSON*, C.; SONESSON, C.; SANDAHL, A.; GREINER, H. E.; GASSEN, M.; PLASCHKE, J.; LEIBROCK, J.; BOETTCHER, H.; Bioorg. Med. Chem. Lett. 15 (2005) 19, 4230-4234; Med. Chem., Biotech Cent., Carlsson Res. AB, S-413 46 Goeteborg, Swed.; Eng.) -M. Schroeter 51-127

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Groups. -The title reaction of various bromoindoles is performed with different N-and O-nucleophiles in the presence of CO. A variety of indole carboxylic acid derivatives are accessible in excellent yield including potentially bioactive amphetamine analogues such as (IVc) and (XII). -(KUMAR, K.; ZAPF, A.; MICHALIK, D.; TILLACK, A.; HEINRICH, T.; BOETTCHER, H.; ARLT, M.; BELLER*, M.; Org. Lett. 6 (2004) 1, 7-10; Leibniz-Inst. Org. Katal., Univ. Rostock, D-18055 Rostock, Germany; Eng.) -Steudel 22-127

The synthesis of a major metabolite (I) of vilazodone using a Japp-Klingemann type Frischer-indole synthesis protocol is presented. -(HEINRICH*, T.; BOETTCHER, H.; Bioorg. Med.