No abstract

Highlights of the Study• Three genetic determinants, fusA mutation (fusA), fusB, and fusC, were responsible for fusidic acid resistance in methicillin-resistant Staphylococcus aureus isolates from Kuwait hospitals. • The majority of methicillin-resistant Staphylococcus aureus isolates carried fusC.• Methicillin-resistant Staphylococcus aureus strains belonged to diverse genetic backgrounds.• The high prevalence of fusidic acid-resistant methicillin-resistant Staphylococcus aureus calls for a review of fusidic acid usage to preserve the therapeutic benefit of the antibiotic.