Specific immunotherapy seems to be an effective treatment for cat allergy. Allergy to cats is common and often poorly controlled on conventional pharmacotherapy. Although cat allergy has not traditionally been considered as a valid indication for immunotherapy in the UK, it should now be considered as a legitimate treatment, especially for those who are unable to avoid exposure.

Local endobronchial allergen challenge is being increasingly used to investigate the role of allergic inflammation in asthma. However, little information is available about the safety of this procedure and the changes induced in airway physiology. BAL and biopsy were performed at 10 min and at 4 to 6 h, or 24 h after segmental allergen challenge in 49 patients with atopic asthma. Two hours after challenge, FEV1 was reduced from 97.6 +/- 13.9 (mean +/- SD) to 83.4 +/- 21.7% predicted. FEV1 remained reduced at 4 to 6 h (87.7 +/- 20.4%), but it had nearly returned to baseline by 24 h (93.2 +/- 14.0%). When endobronchial challenge was combined with BAL and biopsy, the initial fall in FEV1 was slightly greater (from 101.8 +/- 14.2 to 78.5 +/- 13.6%). Bronchial responsiveness to methacholine was measured in 10 subjects, and it showed a twofold increase 24 h after local challenge and lavage. Significant changes in FEV1 and methacholine PC20 were still detectable 72 h after challenge. Widespread wheezing occurred in 29% of the subjects, but none of the them had to be admitted to hospital. We conclude that local endobronchial allergen challenge, although producing measurable changes in airway physiology, is in general well tolerated and is an acceptable method to investigate airway pathophysiologic processes in patients with mild to moderate asthma.

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Background. Promoting positive health choices is one way to lessen health care disparities in indigent populations. This pilot study investigated satisfaction with the health information received at an urban heath care center for the indigent and its effect on health behaviors. Such information will inform providers on their role in advancing the health center's quality improvement goals (i.e., goals used to measure the clinic's performance in providing preventive service information to patients). Methods. A survey was used to determine respondent satisfaction with health care information and whether respondents would make positive health choices based on this information. Results. Respondents (n = 185) were satisfied with the health information received; this was the most consistent predictor of making a lifestyle change. Minority respondents were more likely to get a vaccination, to not start smoking, and to start exercising than non-minority respondents. Conclusion. The results suggested that, for the positive health choices examined, satisfaction with education is very important. For certain positive health choices, race also may play a role. Additional studies should be undertaken linking chronic health problems to patient responses. KS J Med 2014; 7(1):88-95.