Seat upholstery fabrics for vehicles are crucial products as technical textiles in motor vehicles make up approximately 15% of the total manufactured technical textiles worldwide and more than 50% of the production belongs to the woven fabrics because of their appropriate properties for this application. The current work presents the comfort-related properties of the woven fabrics designed to be used in automotive seat upholstery. For this aim, double-layered woven fabrics were produced with four different process variables such as bottom layer pattern, number of interlacing warps in a unit report, number of interlacing picks per top warp, and number of weft skips by using Taguchi experimental design. Besides handle related properties, such as circular bending rigidity, surface roughness properties, and thermo physiological comfort related properties that include air permeability, thermal resistance, and moisture management properties were measured and analyzed based on Taguchi experimental analysis.